Updating risk prediction tools a case study in prostate cancer

This year, pancreatic cancer surpassed breast cancer to become the third-leading cause of cancer deaths in the United States.By 2020, it is expected to replace colon cancer as the second-leading cause of cancer deaths.SEARCH strategy: A validated search strategy for the retrieval of primary studies for systematic reviews of risk prediction modelling studies was published in 2012.

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But when detected in its earliest stages before symptoms arise, cure rates approach 75 percent.

In this way, risk calculators offer a logical and systematic approach to the use of patient risk factors, which can then be used to influence clinical decision-making.

The ERSPC risk calculator has seven steps based on seven different logistic regression models (3) and is internet-based (prostatecancer-riskcalculator.com).

The different steps were created using a subset of patients from the European Randomized Study of Screening for Prostate Cancer (4) and each seeks to offer an individual man’s risk of prostate cancer (PCa).

The different steps of the ERSPC risk calculator are outlined below in have examined the potential impact of updating the outcome measure that is being predicted by the ERSPC step 3 risk calculator (5).

Updating risk prediction tools a case study in prostate cancer